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KMID : 1001020100080020065
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Korean Journal of Urological Oncology
2010 Volume.8 No. 2 p.65 ~ p.70
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Metabolic Change after Androgen Deprivation Therapy in Korean Men with Prostate Cancer
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Park Chang-Hoo
Sung Gi-Teck
Kim Sea-Young
Kim Sung-Jin
Hong Sung-Woo
Kim Jong-Won
Park Chang-Myun
Kim Han-Gwun
Park Jong-Yeon
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Abstract
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Purpose: In men with prostate cancer, Androgen deprivation therapy shows a variety of well recognized metabolic alteration. But it is not known in Korean men with prostate cancer. To better characterize the metabolic effects of androgen deprivation therapy in Korean men, we evaluated the changes in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol.
Materials and Methods : From December 2002 to December 2008, 148 Korean men treated with leuprolide depot and bicalutamide for prostate cancer and 100 healthy subjects were investigated included change from baseline to month 12 in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol. Fat thickness was estimated from subcutaneous fat thickness at T10 level through CT or MRI image. We also compared them with data from healthy subjects.
Results: The mean fat thickness was significantly increased by 22.9% from baseline (16.6mm) to month 12 (20.4mm) in men with prostate cancer (p＜0.001). The BMD was significantly decreased by 4.2% from 0.95 to 0.91 (p＜0.001). The BMI was significantly increased by 4.8% from 23.0kg/m2 to 24.1kg/m2 43 (p＜0.001). The hemoglobin level was significantly decreased. In contrast, the cholesterol levels did not change significantly. The patients with prostate cancer had significant changes in fat thickness, BMD, and BMI, compared with healthy subjects (p＜0.005, respectively). But there are no significant changes in hemoglobin and cholesterol levels.
Conclusions : Our results show that Korean men with prostate cancer have increased abdominal subcutaneous fat and BMI and have decreased BMD during androgen deprivation therapy. These increases the risk of bone fracture and obesity related complication. Therefore, BMD will be checked periodically and carry out exercise program to prevention obesity during androgen deprivation therapy.
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KEYWORD
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Prostate cancer, Metabolic disorder, Body mass index
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